abstract：:P-glycoprotein, a pump located in the plasma cell membrane, extrudes several clinically important drugs from the cell, and hence causes multidrug resistance. Reversing clinical drug resistance is possible by using agents that inhibit the activity of P-glycoprotein. We describe the results of sequential flow cytometric...

journal_title：Acta clinica Belgica

authors： De Moerloose B,Muylaert A,Gemmel F,Janssens A,Poppe B,Dhooge C,Benoit Y,Van Hove W,Philippé J

更新日期：2000-07-01 00:00:00

abstract：:Over the past few years there have been enormous changes in the management of stroke patients. General practitioners, ambulance personnel/paramedics and the general public need to be well informed that stroke is a medical emergency. Prevention of secondary brain damage by normalising vital parameters and combating fev...

journal_title：Acta clinica Belgica

authors： De Keyser J,Sulter G,Langedijk M,Elting JW,van der Naalt J

更新日期：1999-10-01 00:00:00

abstract：:Sepsis is characterized by disturbances in liver perfusion and alterations in intrahepatic cellular functions and interactions. This provokes structural and functional liver damage as well as hepatocellular activation that is believed to perpetuate the immuno-inflammatory response. Changes in hepatic perfusion during ...

journal_title：Acta clinica Belgica

authors： Smets D,Spapen H,Diltoer M,Nguyen DN,Hubloue I,Huyghens L

更新日期：1999-08-01 00:00:00

abstract：:In order to demonstrate an intake of cannabis, there are a number of rapid tests, all of them being focused on urine. In this study, we evaluated the results of six tests when applied to sweat (DrugWipe), saliva and urine (Syva Rapidtest, Biomedix, Frontline, DrugWipe, Cortez Dako). Fifty regular users of cannabis and...

journal_title：Acta clinica Belgica

authors： Mura P,Kintz P,Papet Y,Ruesch G,Piriou A

更新日期：1999-01-01 00:00:00

abstract：:Within the scope of an information campaign of the Belgian Institute for Road Safety an attempt was made to classify 179 medicinal drugs from 9 therapeutic groups, listed in the Belgian "Commented Repertory of Drugs--1997", according to their effect on driving performance. The categorisation was based on literature da...

journal_title：Acta clinica Belgica

authors： Maes V,Grenez O,Charlier C,Smet H,Verstraete A,Wennig R

更新日期：1999-01-01 00:00:00

abstract：:A detailed retrospective analysis of 8 cases has been set up to obtain an update of the clinical, radiological, diagnostic and therapeutical aspects of pulmonary Langerhans' cell granulomatosis (PLCG), previously called Histiocytosis X. This disease represents 2.8% of interstitial lung diseases (ILD) in a registration...

journal_title：Acta clinica Belgica

authors： Callebaut W,Demedts M,Verleden G

更新日期：1998-10-01 00:00:00

abstract：:We report the case of a 25 year old male who presented with a well-circumscribed mass in the infratemporal fossa, without intracranial localisation. On histological examination, this tumor was a transitional type of meningioma. We review the literature and discuss the pathogenesis and the differential diagnosis. ...

journal_title：Acta clinica Belgica

authors： Galant C,Rombaux P,Hamoir M,Marbaix E,Gosseye S

更新日期：1998-08-01 00:00:00

abstract：:We report about 2 cases of isolated mediastinal tuberculous lymphadenitis presenting without parenchymal infiltrates. Although rare, this mode of presentation reminds the clinician that tuberculosis has to be included in the differential diagnosis of mediastinal masses even in the absence of parenchymal lesion. Both c...

journal_title：Acta clinica Belgica

authors： Hainaut P,Monthe A,Lesage V,Weynand B

更新日期：1998-04-01 00:00:00

abstract：:Malignant insulinomas are very rare. They have typical clinical and biochemical characteristics that allow an early detection and distinction from other sorts of islet cell carcinoma. As a result a curative resection can occasionally be managed. Nevertheless, for more advanced stages the same treatment options as for ...

journal_title：Acta clinica Belgica

authors： Berwaerts J,Verhelst J,Hubens H,Kunnen J,Schrijvers D,Joosens E,Mahler C,Van Gaal L

更新日期：1997-01-01 00:00:00

abstract：:The authors report the cases of two patients suffering from ascites attributed for several years to a non pericarditic aetiology. The first patient presented with a diagnosis of right cardiac failure secondary to a right myocardial infarction. Cardiac catheterisation, magnetic resonance imaging and transoesophageal ec...

journal_title：Acta clinica Belgica

authors： Heureux F,Frankart L,Marchandise B,Buche M,Martinet JP,Donckier J

更新日期：1997-01-01 00:00:00

abstract：:The in vitro activity of cefepime has been compared with that of cefotaxime, ceftazidime, aztreonam, and piperacillin against 1826 Enterobacteriaceae including 537 inducible Enterobacteriaceae (Enterobacter spp., Serratia spp., Citrobacter spp,. Morganella morganii) and 572 non-fermenters, including 401 Pseudomonas ae...

journal_title：Acta clinica Belgica

authors： Verbist L,Glupczynski Y

更新日期：1996-01-01 00:00:00

abstract：:Various treatments for essential hyperhidrosis are available. The aim of this study is to present our experience with a simplified thoracoscopic sympathicolysis technique in this disorder, and to confront our results with data in the literature, 35 consecutive patients (11 male, 24 female, age 12-44 years) with essent...

journal_title：Acta clinica Belgica

authors： Noppen M,Vincken W,Dhaese J,Herregodts P,D'haens J

更新日期：1996-01-01 00:00:00

abstract：:The authors report the case of a 67-year-old woman, with mitral valve prolapse, for more than 20 years. She recently complained of attacks of syncope and clinical ventricular tachycardia; ventricular fibrillation was induced during programmed stimulation. The patient seemed to be at high risk for sudden cardiac death,...

journal_title：Acta clinica Belgica

authors： Van Caenegem O,Chaudron JM,Scavée C,de Meester A

更新日期：1996-01-01 00:00:00

abstract：:Tramadol is a weak opioid with effects on adrenergic and serotonergic neurotransmission that is used to treat cancer pain and chronic non malignant pain. This drug was initiated in association with paroxetine and dosulepine hydrochloride in a tetraparetic patient with chronic pain. Fifty-six days after initiation of t...

journal_title：Acta clinica Belgica

authors： Devulder J,De Laat M,Dumoulin K,Renson A,Rolly G

更新日期：1996-01-01 00:00:00

abstract：:In humans, rabies still is a fatally evolving encephalomyelitis caused by a Rhabdovirus of the genus Lyssavirus. In general, the disease is contracted through a contact with an infected mammal. Taxonomically, different rabies and closely related rabies-like viruses can be distinguished. New molecular identification te...

journal_title：Acta clinica Belgica

authors： Vanhoof R,Costy F

更新日期：1996-01-01 00:00:00

abstract：:A multihospital study allowed us to follow a total of 62 serologically proven cases of Nephropathia epidemica (NE) in the Belgian region between Sambre and Meuse during the 1992-1993 period. The clinical picture consisted of sudden high fever (100% of the cases), headache (71%), abdominal or lumbar pains (80%) and, as...

journal_title：Acta clinica Belgica

authors： Colson P,Damoiseaux P,Brisbois J,Duvivier E,Levecque P,Roger JM,Bouilliez DJ,McKenna P,Clement J

更新日期：1995-01-01 00:00:00

abstract：:The authors report an observation of Wegener's granulomatosis with pulmonary, bronchial, renal, cutaneous and sinusal involvement. Five years ago, the patient was referred to us because of bilateral diffuse pulmonary infiltrates of unknown origin. A corticotherapy was introduced at that time and a complete clearance o...

journal_title：Acta clinica Belgica

authors： Polus M,Hamels J,Dorzee J,Henkinbrant A,Carlier B,d'Odemont JP

更新日期：1995-01-01 00:00:00

abstract：:The use of heparin may be complicated by two types of thrombocytopenia (HAT): type I occurs early, is transient, and has no clinical relevance, while type II may lead to very severe manifestations (arterial or venous thromboses and more rarely bleedings), that are still underestimated by some clinicians. HAT-type II m...

journal_title：Acta clinica Belgica

authors： Fondu P

更新日期：1995-01-01 00:00:00

abstract：:The National Institute for Insurance of Disease and Disablement (RIZIV/INAMI) in Belgium reimburses the costs of long term oxygen therapy (LTOT) by concentrators since 1984 and by liquid oxygen since 1988 for specific categories of patients supervised by approved medical centers. Since then we prescribed these therapi...

journal_title：Acta clinica Belgica

authors： Buyse B,Demedts M

更新日期：1995-01-01 00:00:00

abstract：:We retrospectively studied 29 cases of S.pyogenes bacteremia, treated from September 1985 through September 1993, in order to define the clinical pattern, predisposing factors and the outcome of S.pyogenes bacteremia in our region. The number of infections, the clinical picture and mortality rate of S.pyogenes bactere...

journal_title：Acta clinica Belgica

authors： Van de Mierop F,Knockaert DC,De Raedt S,Verhaegen J,Peetermans WE

更新日期：1995-01-01 00:00:00

abstract：:Histiocytosis X of the lung is associated with bone lesions in 4 to 20%. We report a case in which the diagnosis was missed in spite of repeated bronchoscopies with transbronchial lavage. The diagnosis was finally established by isotope bone scan, subsequent skeletal CT-scan and bone biopsy. ...

journal_title：Acta clinica Belgica

authors： Vandeurzen K,Delanote M,Verschakelen J,Sciot R,Decramer M

更新日期：1994-01-01 00:00:00

abstract：:The last decade an increase has been seen in drug smuggling. Body-packing and body-stuffing are the terms used for intracorporeal concealment of illicit drugs (mainly cocaine and heroine, but sometimes also amphetamines and cannabinoids). These body-packets are especially prone to rupture. In order to avoid systemic c...

journal_title：Acta clinica Belgica

authors： Malbrain ML,Neels H,Vissers K,Demedts P,Verbraeken H,Daelemans R,Wauters A

更新日期：1994-01-01 00:00:00

abstract：:Almost all epidemiologic studies have shown that the age-adjusted incidence of osteoporotic hip fracture has been increasing during the last decades. Although the age-related bone loss is considered to be a crucial determinant of the incidence of hip fracture, spontaneous fractures appear to be uncommon: about 90% of ...

journal_title：Acta clinica Belgica

authors： Boonen S,Dequeker J,Pelemans W

更新日期：1993-01-01 00:00:00

abstract：:Estrogen treatment in high doses is effective in reducing adult stature in constitutionally tall girls. In this study, growth data of 38 normal girls with a predicted final height beyond 178 cm, are reported. They were treated with ethinyloestradiol in a daily dose of 0.200 mg until the epiphyseal plates were practica...

journal_title：Acta clinica Belgica

authors： Du Caju MV,Bleyaert S,Op De Beeck L

更新日期：1993-01-01 00:00:00

abstract：:We have studied the clinical characteristics of 126 insulin-treated diabetic patients, mainly type I subjects, who regularly performed during 18 months home glucose monitoring. The numbers of strips used each month was of 60 +/- 33 (mean +/- lSD). During the study period, HbA1C levels decreased from 8.6 +/- 2.1 to 7.0...

journal_title：Acta clinica Belgica

authors： Buysschaert M,Lambert L,Donckier J,Jamart J

更新日期：1993-01-01 00:00:00

abstract：:Type 1 (insulin-dependent) diabetes mellitus is a frequent chronic disease that affects children as well as adults. The disease keeps a life-long burden on patients, their environment and society. Although still incompletely understood, its pathogenesis becomes progressively unravelled. Autoimmune phenomena play an im...

journal_title：Acta clinica Belgica

authors： Gorus FK,Anselmo J,Keymeulen B

更新日期：1993-01-01 00:00:00

abstract：:A case of double neutrophilic population in a more or less symptomless patient is described. The diagnosis is made on one hand by the presence of 2 distinct neutrophil clusters on the PEROX display of the H* 1 hematological automate, on the other hand by cytochemical peroxidase staining which clearly confirms the exis...

journal_title：Acta clinica Belgica

authors： Kutter D,Thoma J,al-Haidari K,Trierweiler P

更新日期：1993-01-01 00:00:00

abstract：:Coronary artery disease is frequently associated with disturbed blood lipids and with a deficient blood fibrinolytic capacity. In order to investigate a possible link between hypercholesterolemia and hypofibrinolysis, we have investigated the effect of simvastatin, a HMG-CoA reductase inhibitor, on blood lipids and fi...

journal_title：Acta clinica Belgica

authors： Jacobs H,Van de Werf F,Lesaffre E,De Geest H,Collen D

更新日期：1992-01-01 00:00:00

abstract：:The hepatotoxicity of tetracyclines is well known. If microvesicular steatosis due to a high dose of tetracycline has virtually disappeared, it can also be observed with other drugs belonging to the tetracycline family. To our knowledge, hepatotoxicity induced by doxycycline has never been reported. In our patient, th...

journal_title：Acta clinica Belgica

authors： Lienart F,Morissens M,Jacobs P,Ducobu J

更新日期：1992-01-01 00:00:00

abstract：:We report the findings in 21 Belgian patients (12 males and 9 females, median age 61 years) with LGLPD. Symptoms at presentation included infection (n = 9), weight loss (n = 5), asthenia (n = 9), pruritus (n = 2) and arthralgia (n = 7). Four patients were asymptomatic. The main clinical findings were hepatomegaly (n =...

journal_title：Acta clinica Belgica

authors： Pierre PG,Bosly A,De Bock R,Debusscher L,Ferrant A,Feremans W,Lacor P,Michaux JL,Van Camp B,Van Hoof A

更新日期：1992-01-01 00:00:00

abstract：:The frequency of neurologic involvement in sarcoidosis is about 5%. When the clinical picture presents with only neurological manifestations, as it did in our patient, the diagnosis at presentation is often difficult. Involvement of other tissues must therefore be actively searched. We describe a case of neurosarcoido...

journal_title：Acta clinica Belgica

authors： Vanhoof J,Wilms G,Bouillon R

更新日期：1992-01-01 00:00:00

abstract：:The arrival of new cephalosporins faces the clinician with an evergrowing confusion as to the drug of choice. The older agents (cephalexin, cephradine, cefadroxil and cefaclor) and the newer formulations cefatrizine and cefuroxime axetil are intensively used for treatment of mild and moderate infections. The oldest ag...

journal_title：Acta clinica Belgica

authors： Verhaegen J,Verbist L

更新日期：1992-01-01 00:00:00

abstract：:Prototheca zopfii, an alga-like organism, was isolated from subungual material in a patient with onycholysis. This organism seldom causes human infections. Clinical and laboratory aspects are described. The literature is reviewed. ...

journal_title：Acta clinica Belgica

authors： Magerman K,Gordts B,Hindryckx P,Van Landuyt HW

更新日期：1991-01-01 00:00:00

abstract：:The present study compares two new factor VIII preparations currently used in the treatment of haemophilia. A Factor VIII was partially purified from plasma obtained from unpaid voluntary Belgian donors in the blood transfusion centers of Lille and Amsterdam and virus-inactivated by exposure to solvent-detergent (FVII...

journal_title：Acta clinica Belgica

authors： Peerlinck K,Arnout J,Tamise M,Vanherle A,Fondu P,Vermylen J

更新日期：1991-01-01 00:00:00

abstract：:Lipoprotein(a) has many similarities to low density lipoproteins but possesses a unique protein moiety called apolipoprotein(a). The plasma concentration of lipoprotein(a) is mainly under genetic control and most of diets and hypolipidemic drugs do not change its level. Only nicotinic acid and neomycin are able to red...

journal_title：Acta clinica Belgica

authors： Heller FR,Parfonry A,Hondekijn JC

更新日期：1991-01-01 00:00:00

abstract：:We compared the technique of immunofluorescence on clinical samples (IFCS) and immunofluorescence on centrifuged cell cultures (IFCC) for the detection of respiratory viruses, using monoclonal antibodies. Four hundred fourty five nasopharyngeal aspirates were tested prospectively for RSV, influenza- (A and B), parainf...

journal_title：Acta clinica Belgica

authors： Pattyn SR,Provinciael D,Lambrechts R,Ceuppens P

更新日期：1991-01-01 00:00:00

abstract：:A patient with severe rheumatoid arthritis received d-penicillamine treatment for 16 months. She developed mild pruritus 6 months after d-penicillamine initiation, and severe pemphigus 10 months after d-penicillamine was changed to azathioprine. Subsequent methylprednisolone pulse therapy resulted in a transient clini...

journal_title：Acta clinica Belgica

authors： Wouters EA,De Clerck LS,Francx L,Stevens WJ

更新日期：1990-01-01 00:00:00

abstract：:The term "microvesicular steatosis of the liver" refers to a variant form of hepatic fat accumulation whose histologic features contrast with the much more common macrovesicular steatosis. Microvesicular steatosis of the liver was originally described in association with conditions who share a number of biochemical an...

journal_title：Acta clinica Belgica

authors： Hautekeete ML,Degott C,Benhamou JP

更新日期：1990-01-01 00:00:00

abstract：:A 61-year-old woman presented with recurrent pleuro-pericarditis following Nissen fundoplication. A diagnosis of anterior gastrodiaphragmatic fistula was made. The suspected etiology of the fistula was local ischemia. This kind of fistula, although exceptional, should always be considered in the presence of unexplaine...

journal_title：Acta clinica Belgica

authors： Descamps OS,Donckier JE,Collard JM,Michel L,Trigaux JP,Melange M,Buysschaert M

更新日期：1990-01-01 00:00:00

abstract：:Primary sclerosing cholangitis (PSC) and idiopathic pulmonary fibrosis (IPF) were each separately described in association with a variety of chronic idiopathic inflammatory diseases such as retroperitoneal fibrosis, Sicca complex or Riedel's thyroiditis. We report a case which may be the first description of the assoc...

journal_title：Acta clinica Belgica

authors： Jonard P,Geubel A,Wallon J,Rahier J,Dive C,Meunier H

更新日期：1989-01-01 00:00:00